The San Francisco 49ers will start Nick Mullens at quarterback for Game 3 at the New York Giants with Jimmy Garoppolo injured.

Mullens will be making his first start since Dec. 30, 2018, which was the final appearance in an eight-game stretch for him as the starter after Garoppolo tore his left ACL in Week 3 of that season. He threw for 2,277 yards with 13 touchdowns and 10 interceptions for a passer rating of 90.8 as the Niners went 3-5 in his starts.

C.J. Beathard will serve as backup.

The 49ers will also be without George Kittle and Raheem Mostert.

The San Francisco 49ers are likely to start Nick Mullens at quarterback in Week 3 against the New York Giants.

Jimmy Garoppolo's sprained ankle is expected to sideline him.

"I'll be surprised if Jimmy gets back later in the week," Kyle Shanahan said. "Nick is ready to go. He got a lot of playing time with us in 2018, and that prepared him for moments like this."

Mullens started eight games for the 49ers in 2018.

The NFL has issues significant fines to Vic Fangio, Pete Carroll and Kyle Shanahan for not wearing masks on Sunday.

Each of the three coaches received a personal fine of $100,000, while their teams were each fined another $250,000.

The NFL issued a warning after Week 1 to coaches to wear their mask on the sideline.

Ziggy Anash has agreed to a one-year, $3 million deal with the San Francisco 49ers.

Anash will boost the 49ers' pass rush after they lost Joey Bosa for the season with a torn ACL.

The San Francisco 49ers believe Nick Bosa suffered a torn ACL in his left knee.

Bosa was engaged with Jets tight end Trevon Wesco on a running play when his left leg buckled as he attempted to get off the block and get to Frank Gore.

Bosa was carted off the field.

Raheem Mostert left the San Francisco 49ers' Week 2 win at the New York Jets with a knee injury.

The 49ers believe Mostert suffered a sprained MCL.

It was unclear exactly when Mostert suffered the injury.

Mostert had eight carries for 92 yards and a touchdown and two catches for 15 yards before his day came to an end.

George Kittle has been ruled out of the San Francisco 49ers' Week 2 game at the New York Jets with a knee injury.

Kittle won't travel with the 49ers to New Jersey, but instead meet them in West Virginia where they will be staying ahead of their Week 3 game back in New Jersey against the New York Giants.

Kittle had four catches for 44 yards.

In need of depth at wide receiver, the San Francisco 49ers have signed Mohamed Sanu to a one-year deal.

Kyle Shanahan hinted at the addition during a new conference on Monday.

"We'll see how these injuries go, but I love Sanu," Shanahan said. "He's a hell of a player, so him being out there is always a possibility ... I wouldn't rule that out at all. He's available and he's definitely a guy I really respect and I think everyone in this league respects. So, we'll see how it goes this week."

Sanu was expected to report to the 49ers on Tuesday night. Due to COVID-19 protocols, the earliest the wide receiver could practice is Friday.

George Kittle suffered a sprained left knee in the San Francisco 49ers' season-opening loss to the Arizona Cardinals.

The injury puts Kittle's status for Week 2 against the New York Jets in question.

"We'll see how he comes in on Wednesday," Kyle Shanahan said. "He was a little sore today but we'll wait to see how he is on Wednesday to see if he's able to practice or be able to go this week. We know there will be some question."

Kittle had four catches for 44 yards in the first half, but was not targeted in the final two quarters.

The tight end suffered what Shanahan called a "popped capsule" in his left knee in a Week 9 win at Arizona in which he also returned and finished the game.

The San Francisco 49ers and New Orleans Saints are the favorites to represent the NFC in the Super Bowl.

The 49ers' odds are at +500 while the Saints are at +550. The implied odds of the 49ers winning the conference are at 16.7 percent.

The Tampa Bay Buccaneers (+600), Dallas Cowboys (+650) and Seattle Seahawks (+750) round out the top-5.

Washington has the longest odds at +10,000.