George Kittle suffered a sprained left knee in the San Francisco 49ers' season-opening loss to the Arizona Cardinals.
The injury puts Kittle's status for Week 2 against the New York Jets in question.
"We'll see how he comes in on Wednesday," Kyle Shanahan said. "He was a little sore today but we'll wait to see how he is on Wednesday to see if he's able to practice or be able to go this week. We know there will be some question."
Kittle had four catches for 44 yards in the first half, but was not targeted in the final two quarters.
The tight end suffered what Shanahan called a "popped capsule" in his left knee in a Week 9 win at Arizona in which he also returned and finished the game.