Nick Chubb will miss several weeks after suffering an MCL injury in his right knee.
Doctors believe Chubb will likely miss approximately six weeks.
"What that ends up being, I don't know," Kevin Stefanski said, when asked if the six-week timetable was accurate. "I know Nick Chubb, and I wouldn't put a time frame on it yet.
"Knowing Nick, he's gonna work very hard in rehab. I know that's hard to see your teammate go down like that; but knowing Nick, he will work his butt off to get back."
Kareem Hunt is expected to take over as Cleveland's primary running back with Chubb out.