Jonathan Taylor has been ruled out of Week 5 by the Indianapolis Colts with a sprained ankle.

The Colts have been struggling to generate a consistent running game even with Taylor in the lineup, so his absence will not make things any easier. 

The Colts will lean on some combination of No. 2 running back Nyheim Hines, Deon Jackson and former Broncos star Phillip Lindsay, who is on their practice squad.