The New England Patriots scored 45 points in the second half in their 52-28 victory at the Buffalo Bills.

The Patriots had a +24.1 advantage in The Trench Counter, averaging 9.3 yards per pass, 6.2 yards per rush and 14 more first downs than the Bills. New England had a +13 edge in Total Rushes/Completions.

Tom Brady went 22-for-36 for 340 yards and three touchdowns. Both Wes Welker and Rob Gronkowski eclipsed the 100-yard mark receiving.

But the explosion of the Patriots' running game may be the game's biggest takeaway. Stevan Ridley rushed 22 times for 106 yards and two touchdowns, while Brandon Bolden rushed 16 times for 137 yards and one touchdown, an average of 8.6 yards.

Fred Jackson and C.J. Spiller will both be active for the Buffalo Bills against the Patriots in Week 4.

Jackson injured his knee in Week 1 and recovered more quickly than expected.

Spiller injured his shoulder last week.

Jackson and Spiller are expected to split carries.

The Buffalo Bills improved to 2-1 despite using third-string running back Tashard Choice 20 times for 91 yards following an injury to C.J. Spiller in their 24-14 win at the Cleveland Browns.

The Bills had a +7.1 advantage in the The Trench Counter, averaging 1.1 more yards per pass and 1.6 yards per rush. Buffalo had a +16 edge in Total Rushes/Completions.

Ryan Fitzpatrick went 22-for-35 for 208 yards and three touchdowns without an interception.

Mario Williams recorded 1.5 sacks as the Bills got to Brandon Weeden four times in total.

Weeden went 27-for-43 for 237 yards with one touchdown and two interceptions.

Trent Richardson scored a touchdown but was limited to just 2.3 yards per carry.

The Buffalo Bills and Toronto are nearing agreement on a deal to extend their series of regular season games at the Rogers Centre.

"We'll be having an announcement on that," Rogers Communications vice chairman Phil Lind said Friday. Without providing a timeline, Lind said "It'll be soon."

The extension is expected to last five years, with one annual game in Toronto.

Rogers paid the Bills $78 million for the eight-game series in 2008, but that price is expected to drop.

Toronto is located 100 miles from Buffalo.

Fred Jackson returned to the practice field on Thursday as he recovers from a sprained LCL.

“Yeah he is,” said Chan Gailey about how Jackson is ahead of schedule. ”He must be a fast healer.”

C.J. Spiller has been excellent filling in for Jackson, which may cause the Bills to bring him back slowly.

Jackson has targeted Week 5 for his return.

Robert Griffin III is ranked first by Pro Football Focus in their Race for Rookie of the Year.

Chandler Jones and Dont'a Hightower of the Patriots are ranked second and third as they are part of Bill Belichick's revamped defense.

Bills' tackle Cordy Glenn ranked fourth, followed by Eagles' linebacker Mychael Kendricks.

C.J. Spiller is the NFL's leading rusher with 292 yards and three touchdowns after Week 2.

Spiller has become the featured running back of the Buffalo Bills with Fred Jackson out.

Spiller had already been preparing as though he would start.

“I thought I’ve had great weeks of preparation leading up to games and everything that I’m doing at practice is pretty much just translating over onto Sundays,” he said.

The Bills may have an interesting decision to make when Jackson returns from injury.

“That’s not up to me, that’s up to the coaches,” said Spiller.  “I think they do a great job of making sure that we get all our playmakers on the field at the same time. The only thing I can control is going out there and trying to help my team win my right now until we get him back and the rest of it will take care of itself.”

C.J. Spiller and the Buffalo Bills' offense exploded for 35 points in the first three quarters as they dominated the Kansas City Chiefs to go 1-1 with a final score of 35-17.

The Bills had a +5.2 advantage in The Trench Counter, though much of the gains made by the Chiefs to make that close came in garbage time. Kansas City had a +1 advantage in Total Rushes/Completions.

Spiller had 123 yards on 15 carries and two touchdowns, along with three receptions for 47 yards in what is quickly becoming a breakout season.

Ryan Fitzpatrick went 10-for-19 for 178 yards and two touchdowns.

Dwayne Bowe finished with 102 yards on eight receptions and two touchdowns, both of which came when the game was decided.

The Buffalo Bills have a 2-9 record since Ryan Fitzpatrick signed his extension last season.

Fitzpatrick has thrown 20 interceptions against 15 touchdowns during the time frame.

The Denver Broncos had the best DVOA in Week 1 as they defeated the Pittsburgh Steelers, followed by the Baltimore Ravens over the Cincinnati Bengals and New England Patriots over the Tennessee Titans.

Football Outsiders also has a stat calle DAVE, which stands for DVOA Adjusted for Variation Early. After Week 1, DAVE accounts for 90 percent and the current VOA counts for 10 percent.

The Patriots rank first in DAVE at 41.0%, followed by the Falcons, Packers, Bears and Ravens. 

Here are the full rankings for DAVE with the preseason DVOA ranking in parentheses: 

1. Patriots (1)
2. Falcons (3)
3. Packers (2)
4. Bears (6)
5. Ravens (7)
6. Jets (8)
7. Broncos (11)
8. Saints (5)
9. Steelers (4)
10. Texans (13)
11. Eagles (12)
12. Cowboys (14)
13. Panthers (10)
14. Giants (9)
15. Buccaneers (22)
16. Lions (21)
17. Chiefs (15)
18. 49ers (23)
19. Chargers (19)
20. Bills (16)
21. Titans (17)
22. Redskins (20)
23. Raiders (24)
24. Bengals (18)
25. Vikings (29)
26. Seahawks (28)
27. Jaguars (26)
28. Dolphins (25)
29. Colts (27)
30. Cardinals (30)
31. Browns (31)
32. Rams (32)