Drew Brees broke Peyton Manning's career touchdown record with a 5-yard pass to Josh Hill midway through the third quarter on Monday night.
The connection with Hill gave him 540 touchdown passes for his career.
Brees tied Tom Brady with his 538th career TD thanks to a 15-yard pass to Michael Thomas early in the second quarter. He then tied Manning's record at 539 with a 21-yard TD throw to Tre'Quan Smith midway through the second quarter.
Brees also made NFL history by registering a 96.7 completion percentage as the New Orleans Saints trounced the Indianapolis Colts 34-7.
"Listen, it was special, everything about the night," Brees said. "I don't know how they pick 'em. Monday Night Football, playing the Colts, the team that we won the Super Bowl against 10 years ago. So the whole Super Bowl XLIV team is back for the 10th anniversary. And, obviously, national television, big game, and now that record in the balance, as well. It just kind of makes you shake your head. 'Are you kidding me?'"