The San Francisco 49ers have placed George Kittle on injured reserve with a hamstring injury suffered in their Week 1 win over the Seattle Seahawks.

Kittle will miss at least the next four games, which will take place over a 23-game span. Kittle will be ineligible to return before their Oct. 12 game against the Tampa Bay Buccaneers. 

Kittle left Sunday's game with 10:06 left in the second quarter with the hamstring injury after running a route deep down Seattle's sideline.