Nate Solder has opted out of the 2020 season due to concerns over the COVID-19 pandemic.
Solder cited family concerns, including his son's battle with cancer and his own bout with cancer. He also has a newborn son.
Solder was diagnosed with testicular cancer during a routine physical prior to the 2014 season.
Solder signed a four-year, $64 million contract with the Giants in 2018.
Players considered high risk for COVID-19 can earn $350,000 and an accrued NFL season if they opt out.