Michael Crabtree is expected to play for the first time since tearing his Achilles in the spring.
"I'm really ready to play," Crabtree said from his locker Friday. "It's been a long time coming."
"I feel comfortable enough to play," Crabtree added. "I feel great."
Crabtree emerged as a legitimate No. 1 receiver after Colin Kaepernick took over for Alex Smith last season.