The first week of the NFL season is always hard to gauge from a fantasy perspective since the projections are so heavily based on the season-wide projections. There are a few matchups that appear particularly favorable or discouraging based on opposing defenses, but it most closely resembles season projections than any other week of the season. 

Week 1 Projections

Quarterbacks

1. Drew Brees, Saints (Redskins)

2. Aaron Rodgers, Packers (49ers)

3. Matthew Stafford, Lions (Rams)

4. Tom Brady, Patriots (at Titans)

5. Cam Newton, Panthers (at Buccaneers)

6. Michael Vick, Eagles (at Browns)

7. Eli Manning, Giants (Cowboys)

8. Matt Ryan, Falcons (at Chiefs)

9. Philip Rivers, Chargers (at Raiders)

10. Tony Romo, Cowboys (at Giants)

11. Jay Cutler, Bears (Colts)

12. Ben Roethlisberger, Steelers (at Broncos)

13. Carson Palmer, Raiders (Chargers)

14. Peyton Manning, Broncos (Steelers)

15. Robert Griffin III, Redskins (at Saints)

16. Joe Flacco, Ravens (Bengals)

17. Matt Schaub, Texans (Dolphins)

18. Russell Wilson, Seahawks (at Cardinals)

19. Sam Bradford, Rams (at Lions)

20. Josh Freeman, Buccaneers (Panthers)

21. Ryan Fitzpatrick, Bills (at Jets)

22. Andrew Luck, Colts (at Bears)

23. Alex Smith, 49ers (at Packers)

24. John Skelton, Cardinals (Seahawks)

25. Matt Cassel, Chiefs (Falcons)

26. Andy Dalton, Bengals (at Ravens)

27. Jake Locker, Titans (Patriots)

28. Mark Sanchez, Jets (Bills)

29. Blaine Gabbert, Jaguars (at Vikings)

30. Christian Ponder, Vikings (Jaguars)

31. Brandon Weeden, Browns (Eagles)

32. Ryan Tannehill, Dolphins (at Texans)

Running Backs

1. LeSean McCoy, Eagles (at Browns)

2. Arian Foster, Texans (Dolphins)

3. Ray Rice, Ravens (Bengals)

4. Darren McFadden, Raiders (Chargers)

5. Matt Forte, Bears (Colts)

6. Chris Johnson, Titans (Patriots)

7. Steven Jackson, Rams (at Lions)

8. Doug Martin, Buccaneers (Panthers)

9. DeMarco Murray, Cowboys (at Giants)

10. Jamaal Charles, Chiefs (Falcons)

11. Michael Turner, Falcons (at Chiefs)

12. Darren Sproles, Saints (Redskins)

13. Ahmad Bradshaw, Giants (Cowboys)

14. Reggie Bush, Dolphins (at Texans)

15. Fred Jackson, Bills (at Jets)

16. Rashad Jennings, Jaguars (at Vikings)

17. Marshawn Lynch, Seahawks (at Cardinals)

18. Frank Gore, 49ers (at Packers)

19. Toby Gerhart, Vikings (Jaguars)

20. Kevin Smith, Lions (Rams)

21. DeAngelo Williams, Panthers (at Buccaneers)

22. Willis McGahee, Broncos (Steelers)

23. Trent Richardson, Browns (Eagles)

24. Stevan Ridley, Patriots (at Titans)

25. Cedric Benson, Packers (49ers)

26. Donald Brown, Colts (at Bears)

27. Ronnie Brown, Chargers (at Raiders)

28. Maurice Jones-Drew, Jaguars (at Vikings)

29. Peyton Hillis, Chiefs (Falcons)

30. Shonn Greene, Jets (Bills)

31. Evan Royster, Redskins (at Saints)

32. Michael Bush, Bears (Colts)

33. David Wilson, Giants (Cowboys)

34. Isaac Redman, Steelers (at Broncos)

35. Adrian Peterson, Vikings (Jaguars)

36. C.J. Spiller, Bills (at Jets)

37. Mark Ingram, Saints (Redskins)

38. Ryan Williams, Cardinals (Seahawks)

39. Ben Tate, Texans (Dolphins)

40. Jonathan Stewart, Panthers (at Buccaneers)

Wide Receiver

1. Calvin Johnson, Lions (Rams)

2. Larry Fitzgerald, Cardinals (Seahawks)

3. Andre Johnson, Texans (Dolphins)

4. Julio Jones, Falcons (at Chiefs)

5. Brandon Marshall, Bears (Colts)

6. Roddy White, Falcons (at Chiefs)

7. Victor Cruz, Giants (Cowboys)

8. A.J. Green, Bengals (at Ravens)

9. Wes Welker, Patriots (at Titans)

10. Dez Bryant, Cowboys (at Giants)

11. Antonio Brown, Steelers (at Broncos)

12. Greg Jennings, Packers (49ers)

13. Vincent Jackson, Buccaneers (Panthers)

14. Steve Smith, Panthers (at Buccaneers)

15. Percy Harvin, Vikings (Jaguars)

16. Jordy Nelson, Packers (49ers)

17. Hakeem Nicks, Giants (Cowboys)

18. Eric Decker, Broncos (Steelers)

19. Brandon Lloyd, Patriots (at Titans)

20. Marques Colston, Saints (Redskins)

21. Dwayne Bowe, Chiefs (Falcons)

22. Jeremy Maclin, Eagles (at Browns)

23. Mike Wallace, Steelers (at Broncos)

24. Torrey Smith, Ravens (Bengals)

25. Demaryius Thomas, Broncos (Steelers)

26. Miles Austin, Cowboys (at Giants)

27. Steve Johnson, Bills (at Jets)

28. Titus Young, Lions (Rams)

29. DeSean Jackson, Eagles (at Browns)

30. Pierre Garcon, Redskins (at Saints)

31. Justin Blackmon, Jaguars (at Vikings)

32. Malcolm Floyd, Chargers (at Raiders)

33. Darrius Heyward-Bey, Raiders (Chargers)

34. Kendall Wright, Titans (Patriots)

35. Brandon LaFell, Panthers (at Buccaneers)

36. Sidney Rice, Seahawks (at Cardinals)

37. Greg Little, Browns (Eagles)

38. Nate Washington, Titans (Patriots)

39. Mike Williams, Buccaneers (Panthers)

40. Rod Streater, Raiders (Chargers)

Tight End

1. Jimmy Graham, Saints (Redskins)

2. Rob Gronkowski, Patriots (at Titans)

3. Antonio Gates, Chargers (at Raiders)

4. Jermichael Finley, Packers (49ers)

5. Aaron Hernandez, Patriots (at Titans)

6. Vernon Davis, 49ers (at Packers)

7. Fred Davis, Redskins (at Saints)

8. Brandon Pettigrew, Lions (Rams)

9. Tony Gonzalez, Falcons (at Chiefs)

10. Greg Olsen, Panthers (at Buccaneers)

11. Martellus Bennett, Giants (Cowboys)

12. Jared Cook, Titans (Patriots)

13. Kyle Rudolph, Vikings (Jaguars)

14. Owen Daniels, Texans (Dolphins)

15. Coby Fleener, Colts (at Bears)

16. Brent Celek, Eagles (at Browns)

17. Jermaine Gresham, Bengals (at Ravens)

18. Marcedes Lewis, Jaguars (at Vikings)

19. Dustin Keller, Vikings (Jaguars)

20. Jacob Tamme, Broncos (Steelers)

Defensive/Special Teams

1. Eagles (at Browns)

2. Bears (Colts)

3. Texans (Dolphins)

4. Seahawks (at Cardinals)

5. Lions (Rams)

6. Jets (Bills)

7. Packers (49ers)

8. Ravens (Bengals)

9. Vikings (Jaguars)

10. Bills (at Jets)

11. Steelers (at Broncos)

12. Patriots (at Titans)

13. Bengals (at Ravens)

14. Falcons (at Chiefs)

15. 49ers (Packers)

16. Broncos (Steelers)

17. Cardinals (Seahawks)

18. Saints (Redskins)

19. Giants (Cowboys)

20. Chargers (at Raiders)

21. Jaguars (at Vikings)

22. Chiefs (Falcons)

23. Cowboys (at Giants)

24. Raiders (Chargers)

25. Buccaneers (Panthers)

26. Browns (Eagles)

27. Colts (at Bears)

28. Dolphins (at Texans)

29. Panthers (at Buccaneers)

30. Titans (at Patriots)

31. Redskins (at Saints)

32. Rams (at Lions)

- Questions from Twitter are encouraged and will be answered in next week's edition, along with analysis from Week 1.