Eagles running back Brian Westbrook will not play against the 49ers on Sunday.
Westbrook has missed the last four games and six of the last seven with a concussion.
He practiced with Philadelphia's scout team this week, but has not been cleared to play in a game.
In addition, the Eagles will be without rookie wide receiver Jeremy Maclin, who left Sunday night's win over the Giants with a torn plantar fascia.
Westbrook Out Against San Francisco