Buffalo quarterback Trent Edwards left the team's loss to Arizona on Sunday in the first quarter with a concussion. Cardinals' safety Adrian Wilson blitzed untouched and leveled Edwards, slamming him to the ground on just the third play of the game. He lay on the ground for several minutes before being helped to the sideline. He was carted off the field. J.P. Losman took Edwards' place, the Bills ended up losing their first game of the season, 41-17 to the Cardinals.