Steelers' strong safety Troy Polamalu and wide receiver Santonio Holmes seem certain to miss at least one game and possibly more with injuries from a surprise loss to the New York Jets. Polamalu sprained a knee and Holmes injured ankle ligaments during a 19-16 overtime loss Sunday, one of the NFL's biggest upsets this season. Both are listed as doubtful for Monday night's home game against Miami (0-10). Although Coach Mike Tomlin wouldn't list either player as out, he talked Tuesday as if neither would play. Both injuries are the type that can sideline players for multiple games. Tomlin called them "two significant injuries."