It took the Colts one half to shake off their post-Super Bowl hangover. Then Peyton Manning and friends came alive to beat New Orleans 41-10 Thursday night in the NFL's opener, running away in the final 30 minutes with a championship caliber performance. Playing against his hometown team, Manning had three TD passes, two to Reggie Wayne and another to Marvin Harrison. Joseph Addai ran for 118 yards on 23 carries and a super-quick defense with four new starters shut down Drew Brees, Reggie Bush and the explosive New Orleans offense. The game was tied 10-10 after a sloppy first half.