49ers defensive end Nick Bosa's pursuit of a fifth straight game with a sack to start the season ended early Sunday against the Panthers as he departed in the third quarter with a groin injury.

Bosa was the biggest loss for the Niners on a day when they saw two other key contributors leave with injuries. In the first half, San Francisco lost safety Jimmie Ward to a left hand injury and kicker Robbie Gould departed in the third quarter with a left knee injury.