Rushing leader Larry Johnson made the Broncos' fifth-ranked run defense look ordinary.
Johnson ran for 157 yards, Lawrence Tynes kicked four field goals and Kansas City inaugurated the league's new Thanksgiving tripleheader with a 19-10 victory.
The Chiefs (7-4) charged into a second-place tie with Denver in the AFC West and gave the Broncos (7-4) their first two-game losing streak since late in 2004.
Chiefs' Johnson Makes Broncos' Run Defense Look Ordinary