The toe of Terrell Owens has become a major cause for concern in Buffalo.
Owens will miss his second straight preseason game on Saturday because of the injury.
The receiver hasn't taken part in a full practice since Aug. 9 when he aggravated the injury in the Hall of Fame Game.
"He runs a lot," Bills offensive coordinator Turk Schonert said Thursday. "He has to make cuts on that thing, sharp cuts.
"For a lineman, working in short space, it's not going to be as much of a problem. But a receiver or a running back, you've got to make jump cuts and sharp cuts. It's a huge injury."
Owens had issues with the same toe back in 2000 when he was with the 49ers.
T.O.'s Toe Injury Could Become A Major Issue