J.P. Losman will start for the Buffalo Bills against San Diego after Kelly Holcomb missed his third straight practice since getting a concussion. Coach Mike Mularkey said Friday that he expected Holcomb to be medically cleared for the game Sunday, but wasn't sure if he would serve as Losman's backup or be relegated to No. 3 status. Holcomb was hurt when he was sacked and fumbled in the second quarter of Buffalo's 14-3 win against Kansas City on Sunday. It was Holcomb's fifth consecutive start since replacing Losman, who struggled in opening the season at 1-3.