Marqise Lee will miss the 2018 season because of the knee injury he suffered in the Jacksonville Jaguars' third preseason game.
The Jaguars didn't specify the nature of the injury but he will undergo surgery.
Lee, who signed a four-year, $34 million contract ($16.5 million guaranteed) in March, is the Jaguars' most experienced receiver, with 171 catches for 2,166 yards and eight touchdowns in four seasons with the team.
"I feel very confident about the players that we have at that position," Doug Marrone said. "I still it as competition there. We're not settled on some of the spots at receiver, but we feel that we're good enough to go into the season with the guys that we think can make the team."