The Arizona Cardinals lost their first game of the 2012 season, dropping a 17-3 decision to the St. Louis Rams.

The Rams had a -1.7 deficit in The Trench Counter, as they completed eight fewer first downs and more yards lost to penalties. The Cardinals had a +6 edge in Total Rushes/Completions.

Sam Bradford was 7-for-21 for two touchdowns and one interception, while Steven Jackson rushed 18 times for 76 yards.

Kevin Kolb went 28-for-50 for 289 yards, connecting with Larry Fitzgerald eight times for 92 yards.

The Cardinals had success sustaining drives, but the Rams' defense failed to break.