The New Orleans Saints fear Jameis Winston suffered a "significant" knee injury in the team's 36-27 win over the Tampa Bay Buccaneers on Sunday.

"I cried when I saw him coming in," acknowledged Sean Payton, who said he was waiting to speak with doctors before giving a more detailed diagnosis. "It's hard."

Trevor Siemian replaced Winston and led the Saints to an improbable win that was clinched by Tom Brady's third turnover of the game.

Winston was injured during a horse-collar tackle by Devin White -- who was flagged 15 yards for pulling Winston down by the shoulder area of his jersey, forcing Winston to land awkwardly. Winston's left leg got pinned behind him as he hit the turf.