The San Francisco 49ers defeated the Buffalo Bills 45-3 in a performance where they dominated all facets of the game.

The 49ers had a +32.7 advantage in The Trench Counter, averaging 5.5 more yards per play and 19 extra first downs. San Francisco had a +22 edge in Total Rushes/Completions.

The 49ers passed and rushed for 300 yards in each category, the first such feat in NFL history.

Alex Smith went 18-for-24 for 303 yards and three touchdowns, along with another 49 on the ground.

Michael Crabtree caught six balls for 113 yards and a touchdown, while Vernon Davis caught five for 106.

Frank Gore rushed 14 times for 106 yards and a touchdown and Kendall Hunter added 81 yards on 11 carries.