Ben Roethlisberger threw three touchdown passes Thursday as the Steelers beat the Rams 41-24 to inch closer to a postseason berth.
The Steelers improved to 10-5 and will clinch the AFC North division title if the Browns lose to the Bengals on Sunday.
They will book a wildcard berth if the Titans lose to the Jets.
Jacksonville also have a chance to clinch an AFC berth, taking on Oakland on Sunday.
However, the Steelers also suffered another blow on as running back Willie Parker - the NFL's leading rusher with 1,316 yards - broke his right leg in the first quarter.
The injury will keep him out for the remainder of the season.
Steelers Down Rams; Parker Fractures Leg