Louisville quarterback Brian Brohm threw for 375 yards and four touchdowns and the 10th-ranked Cardinals sparkled in coach Steve Kragthorpe's debut, drilling overmatched Murray State 73-10 on Thursday night. Brohm led Louisville (1-0) to touchdowns on each of the Cardinals' first eight drives, guiding an attack that looked awfully similar to the wide-open system that former coach Bobby Petrino used to lead the Cardinals to national prominence.