Drew Lock targeted Jerry Jeudy 15 times on Sunday, but the rookie wide receiver had just six catches for 61 yards.
Jeudy had 5 drops, including two very costly ones.
He has been targeted 91 times this season and caught just 41 passes.
"Sometimes, drops happen," Jeudy said. "I'm watching the ball come in. I just dropped it. And I've just got to focus on the next play. It just happened too many times. That's unacceptable."