Trevor Lawrence of Clemson is the overwhelming favorite to be the first overall selection in the 2021 NFL Draft, according to odds from SportsBetting.ag. Justin Fields of Ohio State has the second best odds at +500.

No. 1 Selection in 2021 NFL Draft
Trevor Lawrence -400
Justin Fields +500
Penei Sewell +1200
Gregory Rousseau +1800
Ja'Marr Chase +2000