Cam Newton has been placed on season-ending injured reserve.
Newton aggravated the Lisfranc injury, originally suffered in the third preseason game, in a Week 2 loss against the Buccaneers.
"For the past seven weeks, Cam has diligently followed a program of rest and rehab and still is experiencing pain in his foot," general manager Marty Hurney said in a statement. "He saw two foot specialists last week who agreed that he should continue that path prescribed by the team's medical staff, and that it likely will take significant time for the injury to fully heal."
Newton had previously only missed three starts in seven seasons.
Newton has one season remaining on his contract with the Carolina Panthers.