Patrick Mahomes "tweaked" his ankle in Sunday night's loss to the Indianapolis Colts, according to Andy Reid.
The Kansas City Chiefs lost their first game of the season 19-13.
"Tweaked it just a little bit. I think he's going to be OK," Reid said. "He was pretty good at the end there. We'll see how that goes."
The Chiefs have a home game against the Houston Texans in Week 6.
"Just reaggravated it a little bit there in the first half and then got stepped on in the second half," Mahomes said. "Obviously it's going to be a little sore tomorrow."
He was 22-for-39 with 321 yards and a touchdown.