Lamar Miller will miss the entire 2019 season with a torn ACL.
Miller suffered the injury during Saturday's preseason game against the Dallas Cowboys.
"It's very difficult to lose a guy like Lamar, for a lot of reasons. He's a great pro. He's just an awesome guy in the locker room," Bill O'Brien said after the game.
Miller had 973 yards on 210 carries last season for the Houston Texans and was entering the final season of a four-year contract.