Andrew Luck will miss the rest of the preseason and could be out for Week 1 due to a high ankle sprain.
"We're 3 1/2 weeks away from the regular season, I'm not ready to say," Colts general manager Chris Ballard said Tuesday night regarding whether Luck will play or not against the Chargers.
Luck was originally diagnosed with a calf strain in March and that has moved into the ankle.
"From the start we've been dealing with a calf injury," Ballard said. "In March through camp, dealing with a calf and then little area below his calf, which Andrew kind of referred to as a lower leg where he was dealing with some pain, almost in the ankle area. The injury wasn't getting better and hadn't been practicing so in the course of dealing with the calf injury, it appears that now we have an ankle issue."