Ray McDonald has been arrested on domestic violence charges.
San Jose police Sgt. Heather Randol confirmed that McDonald, 29, was taken into custody early Sunday after officers responded to a call at 2:48 a.m. PT.
McDonald ranks second among San Francisco 49ers' defensive ends in sacks, snaps and tackles since 2011.
Under the league's newly implemented personal conduct policy, a first domestic-violence offense will result in a six-game ban and a second in a lifetime ban from the NFL.