The San Francisco 49ers will likely be without Bruce Miller for the remainder of the season.

Miller, starting fullback for the 49ers, sustained a serious injury to his left shoulder blade in the 49ers' win on Sunday over the Tampa Bay Buccaneers.

Miller was a Pro Bowl alternate in 2012 and played even better in 2013.

“It’s a very significant loss,” Jim Harbaugh said. “He does so many things in pass protection and the run game, plus receiving out of the backfield. He’s a multi-talented and multi-use player. That’s a loss.”