Skewering a Denver defense that was designed specifically to stop him, Peyton Manning led the Colts over, around and through the Broncos on Sunday, throwing for 345 yards and three touchdowns to Reggie Wayne for a message-sending 34-31 victory. "When you play a guy like Peyton Manning, and the guy's going to put it on there on the money, what can you do?" Broncos cornerback Champ Bailey said.