Redskins running back Tim Hightower is out for the season with a torn ACL in his left knee.
In addition, wide receiver Santana Moss will miss 5-7 weeks with a broken bone in his left hand.
Washington has now lost five offensive starters to significant injuries in the last two games.
Hightower's knee buckled during a third-quarter run in Sunday's 33-20 loss to Carolina.
Redskins Lose Hightower For Season