The Colts pulled a number of their starters, including quarterback Peyton Manning on Sunday, and lost their first game of the season.
The Jets beat the Colts 29-15.
When Indianapolis coach Jim Caldwell pulled some of his starters, at the 5:36 mark in the third quarter, the Colts led 15-10.
The Colts had won 23 straight regular-season games.
Colts Pull Starters, Lose First Game