The Buffalo Bills enter the season as the outright betting favorite for the first time since 1991.
The Bills are seeking their first-ever Super Bowl championship.
Buffalo is listed at +600 at Caesars Sportsbook ahead of their season opener Thursday against the Los Angeles Rams.
The Tampa Bay Buccaneers, at +750, are the second overall Super Bowl favorite, followed by the Rams (11-1) and Green Bay Packers (12-1).