Jeff Heuerman suffered a torn ACL in Saturday and is expected to miss the 2015 season.
The Denver Broncos drafted Heuerman with the 92nd overall pick.
Heuerman was expected to help the Broncos replace Julius Thomas at tight end.
"I feel terrible for Jeff and this is an unfortunate situation," Gary Kubiak said. "Jeff was going to be a big part of our team this year, and he's still going to be a big part of our team and organization in the future.
"He'll get well and be with us as part of this team throughout his rehabilitation."