Derek Wolfe has received a four-game suspension for violating the NFL's policy on performance enhancing drugs.
The fourth-year pass rusher will miss Denver's season-opener against the Ravens along with clashes against the Chiefs, Lions and Vikings.
"During the offseason I took a medication which is on the banned substance list," Wolfe said in the statement released by the team. "The medication is not a substance which would enhance my on-field performance in any way and I genuinely was unaware that it was prohibited, but players are responsible for what is in their bodies.
"I will certainly exercise far greater caution in the future and will seek advice relating to the permissibility of any and all medications."
Wolfe accounted for 1.5 sacks last season along with a respectable 23 quarterback hurries. His strength is stopping the run, with only Seattle's Michael Bennett grading out higher in that category among 4-3 ends in 2014, per Pro Football Focus.