Kelvin Benjamin will miss the entire 2015 season with a torn ACL in his left knee.
Benjamin suffered the non-contact injury during one-on-one drills Wednesday.
"Obviously, we feel awful for Kelvin," general manager Dave Gettleman said. "He’s worked tremendously hard to put himself in a position to have a strong year. We’re confident he will attack his surgery and rehab with the same determination he has met all challenges before."
Benjamin was one of the top performers throughout training camp, and he was poised to build on an impressive rookie season in which he set team rookie records for receptions (73), yards (1,008) and touchdowns (9).