Peyton Manning led the Colts to six scores on his final eight possessions, rallying Indianapolis from an early 10-point deficit to an impressive 38-20 victory Sunday -- giving the Broncos one more anguishing chapter in this lopsided rivalry. But their win wasn't without cost. Eight-time Pro Bowl receiver Marvin Harrison left in the second quarter with a bruised left knee and did not return. Outside linebacker Rob Morris was carted off the field just before halftime with a sprained left knee. Former Pro Bowl safety Bob Sanders (ankle) and running back Joseph Addai (shoulder and back) couldn't finish the game, either.

Rookie Steve Breaston returned a punt 73 yards for a touchdown and the Arizona Cardinals' defense shut down the Pittsburgh Steelers' high-scoring offense most of the day to hand the Steelers their first loss. "It's obviously a special win for me to beat the Steelers," Whisenhunt said, "but I don't have any animosity toward that football team. ... The thing that I'm the proudest about is that our football team beat a good football team that nobody gave us a chance to do." The Cardinals (2-2) ended Willie Parker's string of four consecutive 100-yard rushing games, limiting him to 37 yards in 18 carries. "That had all the makings of a typical loss," Steelers coach Mike Tomlin said. "By that I mean we weren't able to run the ball successfully, the turnovers that we acquired, we gave up a big play and we had way too many penalties. When you do that, you lose."

The sorry state of the San Diego Chargers can be summed up in one word: "MAR-TY! MAR-TY! MAR-TY!" The fans have had it just four games into Norv Turner's tenure as head coach, and Sunday's shocking 30-16 loss to the Kansas City Chiefs -- who rallied for 24 straight points and got huge plays from two rookies -- caused the Chargers fans to lose their Southern California cool. When Rivers threw the last of four straight incompletions from the Kansas City 5-yard line with less than four minutes left, those who weren't streaming out of Qualcomm Stadium started chanting "MAR-TY! MAR-TY! MAR-TY!" in obvious reference to coach Marty Schottenheimer, who was fired in February due to his icy relationship with general manager A.J. Smith.

Picked on for years, the Cleveland Browns finally gave a black eye to one of the NFL's biggest bullies. Derek Anderson threw two touchdown passes, Jamal Lewis ran for one against his former team and the Browns, considered the 98-pound weaklings of the rugged AFC North, surprised the Baltimore Ravens 27-13 Sunday. With their second win over a division opponent this month, the Browns (2-2) looked nothing like the inept team that was embarrassed 34-7 in their home opener three weeks ago by Pittsburgh.

The Dallas Cowboys are 4-0 for the first time since 1995, the year of their last Super Bowl title. Romo was 21-of-33 for 339 yards and three touchdowns, with an interception. He also ran three times for 24 yards en route to a 35-7 Dallas victory over the St. Louis Rams.

The Lions scored an NFL-record 34 points in the fourth quarter as they overcame the Chicago Bears 37-27 Sunday. Jon Kitna threw two touchdown passes in the final quarter as the Lions broke the previous record by three points. Brian Griese, who had three interceptions as a starter in place of Rex Grossman, threw a 1-yard pass to Desmond Clark on a fourth down with 52 seconds left to pull the Bears within three. However, the onside kick bounced to Detroit's Casey FitzSimmons and he returned it for a TD to seal the victory.

Brett Favre was as good as ever, becoming the NFL's all-time leader in career touchdown passes with a couple of vintage third-down zingers to help Green Bay stay unbeaten. Favre was the obvious difference in Sunday's 23-16 victory by the Packers, who hung on against the pass-deficient Minnesota Vikings. He threw No. 421 in the first quarter to Greg Jennings, No. 422 in the fourth quarter to James Jones and went interception-free against a defense determined to make him the league's all-time leader in that category, too. Favre is three picked-off passes away from overtaking George Blanda on the career list.

Trent Edwards did more than deliver the Buffalo Bills a much-needed victory at a time when his demoralized and banged-up team needed it most. The rookie third-round pick, making his first career start, took a big step in showing that he -- and not J.P. Losman -- might be the Bills' quarterback of the future. Edwards is most definitely the quarterback of the present after a poised and efficient performance in a 17-14 win over the New York Jets on Sunday.

Daunte Culpepper dived into the end zone for a touchdown, then rose, tapped his surgically repaired right knee and signaled "OK" to the crowd. His much-scrutinized knee might not be 100 percent, but it was good enough Sunday for Culpepper to lead the Oakland Raiders past the Miami Dolphins. He ran for three touchdowns and threw for two to win the grudge game against his former team, 35-17. Culpepper led the Raiders out of the tunnel before the game, raising his right fist and punching the air as fans booed. He was hardly flashy against his old team, relying on a ground game that totaled 299 yards against an injury-depleted defense.

On this day at least, the Atlanta Falcons didn't need Michael Vick or Matt Schaub. Joey Harrington threw a pair of touchdown passes to Michael Jenkins and 47-year-old Morten Andersen kicked four field goals Sunday, leading the Falcons to their first win of the season, 26-16 over Schaub and the Houston Texans. "We've got a little flow going," Harrington said. "So much of this game is getting on a roll, getting in a groove. We feel like we're starting to dictate what the other team has to do."